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E-4031 dihydrochloride
CAS No. 113559-13-0
E-4031 dihydrochloride ( E4031 )
产品货号. M10476 CAS No. 113559-13-0
E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥308 | 有现货 |
|
| 5MG | ￥494 | 有现货 |
|
| 10MG | ￥786 | 有现货 |
|
| 25MG | ￥1855 | 有现货 |
|
| 50MG | ￥3337 | 有现货 |
|
| 100MG | ￥4965 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称E-4031 dihydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr).
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产品描述E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr), reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents.Heart Arrhythmia Phase 2 Clinical
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同义词E4031
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通路Cell Cycle/DNA Damage
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靶点Potassium Channel
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受体Potassium Channel
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研究领域Cardiovascular Disease
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适应症Heart Arrhythmia
化学信息
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CAS Number113559-13-0
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分子量474.44
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分子式C21H29Cl2N3O3S
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纯度>98% (HPLC)
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溶解度H2O : ≥ 50 mg/mL105.39 mM
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SMILESCC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C.Cl.Cl
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化学全称1-[2-(6-methyl-2pyridyl)ethyl]-4-(4-methylsulfonyl aminobenzoyl)piperidine dihydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Katoh H, et al. J Pharmacol Exp Ther. 1990 Jun;253(3):1077-82.
2. Sano T, et al. Br J Pharmacol. 1990 Mar;99(3):577-81.
3. Lynch JJ Jr, et al. J Cardiovasc Pharmacol. 1990 May;15(5):764-75.
4. Smith JL, et al. Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C919-30.
2. Sano T, et al. Br J Pharmacol. 1990 Mar;99(3):577-81.
3. Lynch JJ Jr, et al. J Cardiovasc Pharmacol. 1990 May;15(5):764-75.
4. Smith JL, et al. Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C919-30.
产品手册
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